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Machine learning applied to gray matter volume data from 61 brain regions identified a combination of 13 regionsincluding the bilateral hypothalamus, right insula, bilateral superior temporal gyrus, and left rostral middle frontal gyrusthat could differentiate tinnitus patients from healthy controls with an accuracy of 80% in a test dataset (Liu et al., 2019)

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Researchers observed that the peptides effects were modulated by NOS inhibitors and NO donors, suggesting involvement of the NO-cGMP signaling axis [4]

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